LATEST Publications

DEVELOPMENT OF A NEW DEVICE FOR ULTRASENSITIVE ELECTROCHEMILUMINESCENCE MICROSCOPY IMAGING   Abstract Electrochemiluminescence (ECL) is widely used in biosensors and immunoassays thanks to the high sensitivity and specificity of the electrochemically triggered luminescence signal. So far, no applications have been reported on the use of ECL as a probe for ultrasensitive lowlightmicroscopeimaging. This work reports […]

PHOTOTHERMAL SENSITISATION AND THERAPEUTIC PROPERTIES OF A NOVEL FAR-RED ABSORBING CYANINE   Abstract A water-soluble disulfonate cyanine was prepared by chemical synthesis and shown to possess photophysical properties which are particularly favourable for the promotion of photothermally sensitised processes, including a very low (

3-(10’-PHENOTHIAZINYL)PROPANE-1-SULFONATE IS A POTENT ENHANCER OF SOYBEAN PEROXIDASE-INDUCED CHEMILUMINESCENCE   Abstract 3-(10’-Phenothiazinyl)propane-1-sulfonate (SPTZ) was shown to be a potent enhancer of soybean peroxidase (SbP)-induced chemiluminescence. To the best of our knowledge, SPTZ is the first enhancer of SbP to be discovered. Optimal conditions for SbP-catalyzed oxidation of luminol in the presence of SPTZ were determined. […]

NEUTRAL AND DIANIONIC RU(II) BATHOPHENANTHROLINEDISULFONATE COMPLEXES: A ROUTE TO ENHANCE ELECTROCHEMILUMINESCENCE PERFORMANCE IN AQUEOUS MEDIA   Abstract We report the strong enhancement of ECL intensity and duration in neutral and dianionic Ru(II) complexes bearing mixed 2,2′-bipyridine (bpy) and bathophenanthrolinedisulfonate (BPS) ligands. In aqueous conditions, using the tripropylamine-assisted method and applying a constant potential, we observed […]

ENHANCED CHEMILUMINESCENCE: A SENSITIVE ANALYTICAL SYSTEM FOR DETECTION OF SWEET POTATO PEROXIDASE   Abstract 3-(10’-Phenothiazinyl)propane-1-sulfonate (SPTZ) was shown to be a potent enhancer of anionic sweet potato peroxidase (aSPP)-induced chemiluminescence. The optimal conditions for aSPP catalyzed oxidation of luminol were investigated by varying the concentrations of luminol, hydrogen peroxide, Tris, and SPTZ as well as […]

ELECTROGENERATED CHEMILUMINESCENCE FOR BIO-ASSAY: FROM SINGLE MOLECULE TO NANO-STRUCTURED TRACERS   Abstract This review provides a basic introduction to the Electrogenerated Chemiluminescence (ECL) technique. The fundamental concepts, mechanisms and bio-analytical applications are briefly discussed. In addition, the trends of current ECL materials research are summarized in relation to their potential use in biological systems. Particular […]

DEVELOPMENT OF ULTRA-SENSITIVE SOYBEAN PEROXIDASE-BASED CL-ELISA FOR THE DETERMINATION OF HUMAN THYROGLOBULIN   Abstract Serum thyroglobulin (Tg) is a main marker of thyroid cancer relapses after total or near-total thyroidectomy of patients with differentiated thyroid carcinoma. In this study, we developed a chemiluminescent enzyme-linked immunosorbent assay (CL-ELISA) for detecting Tg in human serum. Soybean peroxidase […]

ANALYSIS OF THE OXIDO-REDOX STATUS OF PLASMA PROTEINS. TECHNOLOGY ADVANCES FOR CLINICAL APPLICATIONS   Abstract Reactive oxygen species (ROS) are potentially implicated in renal pathology. Direct evidence is available for animal models of glomerulonephritis but the demonstration of ROS implication in human diseases is only circumstantial and requires further experimental support. One problem limiting any […]