Sulfo-SMCC is a heterobifunctional amine to sulfhydryl crosslinking reagent.Sulfo-SMCC contains one sulfo-NHS ester group and a maleimide reactive group at each end of a cyclohexyl spacer.The NHS ester groups readily react towards primary amines at pH 7-9.The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5.The sulfo moieties provide excellent water solubility and allows Sulfo-SMCC to be used in acqueous buffer solutions without the need of organic solvents that may cause protein perturbation.
Properties for Sulfo-SMCC
|Features||Non-cleavable, membrane impermeable and water-soluble heterobifunctional reagent|
|Name||3-sulfo-N-hydroxysuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt|
|Molecular weight||436.37 g/mol|
|Melting point||No data available|
|Storage||Desiccated at -20 °C under Argon. Product is shipped at ambient temperature|
|Solubility||Soluble in cold and hot water|
References for Sulfo-SMCC
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