Sulfo-SMCC Crosslinker Reagent


Sulfo-SMCC Crosslinker Reagent


Sulfo-SMCC is a heterobifunctional amine to sulfhydryl crosslinking reagent. Sulfo-SMCC contains one sulfo-NHS ester group and a maleimide reactive group at each end of a cyclohexyl spacer. The NHS ester groups readily react towards primary amines at pH 7-9.

The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5. The sulfo moieties provide excellent water solubility and allows Sulfo-SMCC to be used in acqueous buffer solutions without the need of organic solvents that may cause protein perturbation.

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Properties for Sulfo-SMCC Crosslinker Reagent

Features Non-cleavable, membrane impermeable and water-soluble heterobifunctional reagent
Name 3-sulfo-N-hydroxysuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate sodium salt
Linear formula C16H17N2NaO9S
Molecular weight 436.37 g/mol
Melting point No data available
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 97%
Identity (NMR) Complies
Solubility Soluble in cold and hot water

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