SIA is a heterobifunctional amine to sulfhydryl crosslinking reagent.SIA contains one NHS ester group and a iodoacetyl reactive group at each end of a short 1.5 angstroms spacer.The NHS ester groups readily react towards primary amines at pH 7-9.The iodoacetyl group reacts towards sulfhydryl (or thiol) groups at pH > 7.5.SIA is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.
Properties for SIA
|Features||Water-insoluble and non cleavable|
|Molecular weight||283.02 g/mol|
|Melting point||144-145 °C|
|Storage||Desiccated at -20 °C under Argon. Product is shipped at ambient temperature|
|Solubility||DMSO, DMF. Water insoluble|
References for SIA
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