SIA Crosslinker Reagent


SIA Crosslinker Reagent


SIA is a heterobifunctional amine to sulfhydryl crosslinking reagent. SIA contains one NHS ester group and a iodoacetyl reactive group at each end of a short 1.5 angstroms spacer. The NHS ester groups readily react towards primary amines at pH 7-9.

The iodoacetyl group reacts towards sulfhydryl (or thiol) groups at pH > 7.5.
SIA is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.

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Properties for SIA Crosslinker Reagent

Features Water-insoluble and non cleavable
Name N-hydroxysuccinimidyl iodoacetate
Linear formula C6H6INO4
Molecular weight 283.02 g/mol
Melting point 144-145 °C
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 97%
Identity (NMR) Complies
Solubility DMSO, DMF. Water insoluble

References for SIA Crosslinker Reagent

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