SATA is a short-chain (2.8 angstroms spacer arm) reagent for covalent modification of primary amines with a protected sulfhydryl, simulating a crosslinking reagent.SATA reacts with primary amines at pH 7-9 and the resulting modified molecule contains a protected reactive group, which can be deprotected to give the reactive thiol by treatment with hydroxylamine-HCl.Before deprotection, the modified molecule can be stored indefinitely.Sulfhydryl groups are important in protein chemistry modification, but are not always present in the molecule of interest.
Properties for SATA
|Features||Non cleavable, amine to thiol modification reagent|
|Molecular weight||231.20 g/mol|
|Melting point||90-93 °C|
|Storage||Desiccated at -20 °C under Argon. Product is shipped at ambient temperature|
|Solubility||DMSO, DMF. Very slightly water soluble|
References for SATA
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