GMBS is a heterobifunctional amine to sulfhydryl crosslinking reagent.GMBS contains one NHS ester group and a maleimide reactive group at each end of an aliphatic 5-atom spacer.The NHS ester groups readily react towards primary amines at pH 7-9.The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5.GMBS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.
Properties for GMBS
|Features||Water-insoluble and non cleavable|
|Name||N-Succinimidyl 4-maleimidobutyrate,4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-maleimidobutyryloxy)-N-hydroxysuccinimide ester|
|Molecular weight||280.20 g/mol|
|Melting point||123-125 °C|
|Storage||Desiccated at -20 °C under Argon. Product is shipped at ambient temperature|
|Solubility||DMSO, DMF. Water insoluble|
References for GMBS
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