GMBS Crosslinker Reagent


GMBS Crosslinker Reagent


GMBS is a heterobifunctional amine to sulfhydryl crosslinking reagent. GMBS contains one NHS ester group and a maleimide reactive group at each end of an aliphatic 5-atom spacer. The NHS ester groups readily react towards primary amines at pH 7-9.

The maleimide group reacts towards sulfhydryl (or thiol) groups at pH 6.5-7.5.
GMBS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.

Properties for GMBS Crosslinker Reagent

Features Water-insoluble and non cleavable
Name N-Succinimidyl 4-maleimidobutyrate,4-Maleimidobutyric acid N-succinimidyl ester, N-(γ-maleimidobutyryloxy)-N-hydroxysuccinimide ester
Linear formula C12H12N2O6
Molecular weight 280.20 g/mol
Melting point 123-125 °C
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 98%
Identity (NMR) Complies
Solubility DMSO, DMF. Water insoluble

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