EGS Crosslinker Reagent


EGS Crosslinker Reagent


EGS is a homobifunctional amine-specific crosslinking reagent based on NHS-ester reactive groups for selective conjugation of primary amines.
EGS contains two NHS ester groups at both ends of a 12-atom spacer that readily react towards primary amines at pH 7-9. EGS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.

EGS is membrane permeable and can be used for intracelular crosslinking. The crosslink formed when using EGS can be cleaved by treatment with hydroxylamine at 35 °C at pH 8.5.

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Properties for EGS Crosslinker Reagent

Features Non-cleavable and membrane permeable
Readily reacts with primary amines in the pH range 7-9
Name Di(N-succinimidyl) ethylene glycol disuccinate, ethylene glycol bis-(N-hydroxysuccinimidylsuccinate)
Linear formula C18H20N2O12
Molecular weight 456.36 g/mol
Melting point 128-132 °C
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 97%
Identity (NMR) Complies
Solubility Acetic acid/water (1:1) up to 50 mg/ml and in DMF

References for EGS Crosslinker Reagent

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