DTSP Crosslinker Reagent


DTSP Crosslinker Reagent


DTSP, also known as Lomant’s reagent is a homobifunctional amine-specific crosslinking reagent based on NHS-ester reactive groups for selective conjugation of primary amines. DTSP contains two NHS ester groups at both ends of a 8-atom spacer that contains a cleavable disulfide bond. The NHS ester groups readily react towards primary amines at pH 7-9.

DTSP is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.
DTSP is membrane permeable and can be used for intracelular crosslinking.
The disulfide bond can be readily cleaved by treatment with DTT or TCEP.

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Properties for DTSP Crosslinker Reagent

Features Non-cleavable and membrane permeable
Readily reacts with primary amines in the pH range 7-9
Name DTSP, 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester), dithio-bis-(N-hydroxysuccinimidyl propionate), Lomant's reagent
Linear formula C14H16N2O8S2
Molecular weight 404.42 g/mol
Melting point 117-119 °C
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 97%
Identity (NMR) Complies
Solubility DMSO, DMF. Water insoluble

References for DTSP Crosslinker Reagent

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