DSS Crosslinker Reagent


DSS Crosslinker Reagent


DSS is a homobifunctional amine-specific protein crosslinking reagent based on NHS-ester reactive groups for selective conjugation of primary amines.
DSS contains two NHS ester groups at both ends of a 8-carbon spacer that readily react towards primary amines at pH 7-9.

DSS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use. DSS is membrane permeable and can be used for the crosslinking of intracelular proteins

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Properties for DSS Crosslinker Reagent

Features Non-cleavable and membrane permeable
Readily reacts with primary amines in the pH range 7-9
Name di-(N-hydroxysuccinimidyl)suberate
Linear formula C16H20N2O8
Molecular weight 368.33 g/mol
Melting point 160-163 °C
Storage Desiccated at -20 °C under Argon. Product is shipped at ambient temperature
Assay ≥ 97%
Identity (NMR) Complies
Solubility DMSO, DMF. Water insoluble

References for DSS Crosslinker Reagent

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