WESTAR ECL Substrates for Western Blotting (two-component)

PRODUCT LINE

WESTAR ECL Substrates for Western Blotting (two-component)

WESTAR is Cyanagen product line of two-component chemiluminescent substrates for Western blotting. Westar products offer different levels of sensitivity for your Western blotting, allowing from picogram to femtogram detection range.

Our proprietary technology enables fine tuning of signal intensity in order to obtain the assay sensitivity and signal duration best suited to meet each experimental need.

Features

  • Compatible with all chemiluminescence imagers and X-ray film detection
  • Well-suited for different types of membranes and blocking reagents as well as a wide range of antibody dilutions
  • Optimized for attaining low background and high signal to noise ratio

Applications

Western Blotting

Products collected in this line

PRODUCT NAME FEATURES CAT: NR
WESTAR SUN Mid picogram detection
Long signal duration
Working solution stable for at least five days
An entry level ECL substrate with excellent performance/price ratio
XLS063
WESTAR NOVA 2.0 Low picogram detection
Ideal for routinary analysis
Working solution stable for at least three days
The best entry level ECL substrate on the market
XLS071
WESTAR ANTARES Mid femtogram detection
Extended signal duration
Working solution stable for at least three days
High range flexibility
XLS142
WESTAR ETA C ULTRA 2.0 Mid to low femtogram detection
The best compromise between high signal intensity and a very long signal duration
A value-priced top performer
Working solution stable for at least three days
XLS075
WESTAR SUPERNOVA Low femtogram detection
Signal intensity equals to current top-level competitors at least
Working solution stable for at least three days
Low antibody consumption to save your money
XLS3
WESTAR HYPERNOVA Detection of trace amounts of proteins
Extreme significance of the experiment
Shortened exposure time
Reduced consumption of antibodies and precious samples
XLS149

Online Resources & Supporting Documents

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Products references of WESTAR ECL Substrates for Western Blotting (two-component) Line

WESTAR SUN
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  • Antczak, Magdalena. “Analiza funkcjonalna wybranych,„sierocych” białek regulatorowych dwukomponentowych systemów transdukcji sygnału u mykobakterii.” (2018).
  • Summer, S. et al. YBEY is an essential biogenesis factor for mitochondrial ribosomes. bioRxiv, 2019.2012.2013.874362 (2019). doi:10.1101/2019.12.13.874362
  • Araújo, Bruna Juber de. “Efeito do óxido nítrico sobre a atividade e expressão da ntpdase1 e da ecto-5′-nucleotidase em linhagens de células vasculares.” (2019).
  • Tapia Ossa, Pablo José. “Mechanisms involved in the loss of brown adipose tissue in the AGPAT2 deficient mouse.” (2019).
  • Dabrowska, M., Ciolak, A., Kozlowska, E., Fiszer, A. & Olejniczak, M. Generation of New Isogenic Models of Huntington’s Disease Using CRISPR-Cas9 Technology. International Journal of Molecular Sciences 21, 1854 (2020).
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WESTAR NOVA 2.0
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  • Santangelo, L. et al. The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting. Cell Rep 17, 799-808 (2016).
  • Castanheira, D.D. et al. Lpx1p links glucose-induced calcium signaling and plasma membrane H+-ATPase activation in Saccharomyces cerevisiae cells. FEMS Yeast Research 18 (2017).
  • Chidgey, J.W., Jackson, P.J., Dickman, M.J. & Hunter, C.N. PufQ regulates porphyrin flux at the haem/bacteriochlorophyll branchpoint of tetrapyrrole biosynthesis via interactions with ferrochelatase. Mol Microbiol 106, 961-975 (2017).
  • Cirillo, F. et al. GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer. Oncotarget 8, 106608-106624 (2017).
  • Correa, M.P., Andrade, F.E.C., Gimenes, A.D. & Gil, C.D. Anti-inflammatory effect of galectin-1 in a murine model of atopic dermatitis. J Mol Med (Berl) 95, 1005-1015 (2017).
  • Lappano, R. et al. The lauric acid-activated signaling prompts apoptosis in cancer cells. Cell Death Discov 3, 17063 (2017).
  • Rainone, P. et al. Development of (99m)Tc-radiolabeled nanosilica for targeted detection of HER2-positive breast cancer. Int J Nanomedicine 12, 3447-3461 (2017).
  • Silva, R.V. et al. Long-chain omega-3 fatty acids supplementation accelerates nerve regeneration and prevents neuropathic pain behavior in mice. Frontiers in pharmacology 8, 723 (2017).
  • Almeida, G.M. et al. Novel selenylated imidazo [1, 2-a] pyridines for breast cancer chemotherapy: Inhibition of cell proliferation by Akt-mediated regulation, DNA cleavage and apoptosis. Biochemical and biophysical research communications 503, 1291-1297 (2018).
  • Andrade, F.E.C. et al. Galectin-3: role in ocular allergy and potential as a predictive biomarker. Br J Ophthalmol 102, 1003-1010 (2018).
  • Andrade, F.E.C. et al. Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus. Br J Ophthalmol 102, 700-707 (2018).
  • Andrade, F.E.C. et al. Evaluation of galectin-1 and galectin-3 as prospective biomarkers in keratoconus. British Journal of Ophthalmology 102, 700-707 (2018).
  • Bdarny, Mai, Manu Prasad, Noa Balaban, Ben-Zion Joshua, Anat Bahat Dinur, Reidar Grenman, Limor Cohen, and Moshe Elkabets. “The AP-1 complex regulates AXL expression and determines sensitivity to PI3Kα inhibition in esophagus and head and neck squamous cell carcinoma.” bioRxiv(2018): 415752. doi:  1101/415752
  • Mello-Bosnic, C., Gimenes, A.D., Oliani, S.M. & Gil, C.D. Treatment with galectin-1 eye drops regulates mast cell degranulation and attenuates the severity of conjunctivitis. Eur J Pharmacol 833, 124-130 (2018).
  • Minchin, R.F., Rosengren, K.J., Burow, R. & Butcher, N.J. Allosteric regulation of arylamine N-acetyltransferase 1 by adenosine triphosphate. Biochem Pharmacol 158, 153-160 (2018).
  • Pang, X. et al. Altered susceptibility to apoptosis and N‑glycan profiles of hematopoietic KG1a cells following co‑culture with bone marrow‑derived stromal cells under hypoxic conditions. Oncology reports 40, 1477-1486 (2018).
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  • Vivacqua, A. et al. miR-338-3p Is Regulated by Estrogens through GPER in Breast Cancer Cells and Cancer-Associated Fibroblasts (CAFs). Cells 7 (2018).
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  • Badarni, M. et al. Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy. JCI Insight 5 (2019).
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  • Cirillo, F. et al. AHR and GPER mediate the stimulatory effects induced by 3-methylcholanthrene in breast cancer cells and cancer-associated fibroblasts (CAFs). J Exp Clin Cancer Res 38, 335 (2019).
  • Dlugosz, P., Tresky, R. & Nimpf, J. Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microscopy. Front Mol Neurosci 12, 53 (2019).
  • Garrido-Rodríguez, M., Ortea, I., Calzado, M.A., Muñoz, E. & García, V. SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone. Journal of proteomics 193, 217-229 (2019).
  • Gianello, V. et al. The PDE4 inhibitor CHF6001 modulates pro-inflammatory cytokines, chemokines and Th1-and Th17-polarizing cytokines in human dendritic cells. Biochemical pharmacology 163, 371-380 (2019).
  • Gimenes, A.D. et al. Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects. J Neuroinflammation 16, 32 (2019).
  • Jentho, E., Novakovic, B., Ruiz-Moreno, C. C., Kourtzelis, I., Martins, R., Chavakis, T., … & Bohm, P. (2019). Heme induces innate immunity memory. bioRxiv. doi: 10.1101/2019.12.12.874578
  • Luo, L. et al. Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus. Sci Rep 9, 13186 (2019).
  • Marmorato, M.P., Gimenes, A.D., Andrade, F.E.C., Oliani, S.M. & Gil, C.D. Involvement of the annexin A1-Fpr anti-inflammatory system in the ocular allergy. Eur J Pharmacol 842, 298-305 (2019).
  • Noce, V. et al. YAP integrates the regulatory Snail/HNF4alpha circuitry controlling epithelial/hepatocyte differentiation. Cell Death Dis 10, 768 (2019).
  • Novoplansky, O. et al. MET activation confers resistance to cetuximab, and prevents HER2 and HER3 upregulation in head and neck cancer. International journal of cancer 145, 748-762 (2019).
  • Roness, H. et al. Pharmacological administration of recombinant human AMH rescues ovarian reserve and preserves fertility in a mouse model of chemotherapy, without interfering with anti-tumoural effects. Journal of assisted reproduction and genetics 36, 1793-1803 (2019).
  • Zhao, P. et al. Sin3a regulates the developmental progression through morula-to-blastocyst transition via Hdac1. FASEB J 33, 12541-12553 (2019).
  • Santini, Silvano Junior, Cristiana Porcu, Giovanni Tarantino, Fernanda Amicarelli, and Clara Balsano. “Oleuropein overrides liver damage in steatotic mice.” Journal of Functional Foods(2020): 103756. doi: 1016/j.jff.2019.103756
  • Stucchi, S. Role of glucose and peroxiredoxin 6 in human chondrocytes and novel biomaterial for in vitro three-dimensional chondrocytes culture. (2020).
  • Wang, H. et al. The nucleolar protein NOP2 is required for nucleolar maturation and ribosome biogenesis during preimplantation development in mammals. FASEB J 34, 2715-2729 (2020).
  • Zhao, P. et al. Essential roles of HDAC1 and 2 in lineage development and genome-wide DNA methylation during mouse preimplantation development. Epigenetics 15, 369-385 (2020).
WESTAR ANTARES
  • Dabrowska, M., Ciolak, A., Kozlowska, E., Fiszer, A. & Olejniczak, M. Generation of New Isogenic Models of Huntington’s Disease Using CRISPR-Cas9 Technology. International Journal of Molecular Sciences 21, 1854 (2020).

 

WESTAR ETA C ULTRA 2.0
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  • Yang, T., Wang, Y., Jiang, S., Liu, X. & Yu, Z. Hepatocyte growth factor‐induced differentiation of bone mesenchymal stem cells toward hepatocyte‐like cells occurs through nuclear factor‐kappa B signaling in vitro. Cell biology international 40, 1017-1023 (2016).
  • 고혜명, 신승식 & 박성수 Gluconacetobacter spp. 스타터로 발효한 콤부차의 생리활성. 한국식품영양과학회지 46, 896-902 (2017).
  • Lo Sciuto, A. et al. Pseudomonas aeruginosa LptE is crucial for LptD assembly, cell envelope integrity, antibiotic resistance and virulence. Virulence 9, 1718-1733 (2018). doi:10.1080/21505594.2018.1537730
  • Mizuno, T., Kinoshita, S., Maedera, S., Ito, T. & Kusuhara, H. Orthogonal linear separation analysis: an approach to decompose the complex effects of a perturbagen. bioRxiv, 384446 (2018). doi:10.1101/384446
  • Pedra, N.S. et al. Endophytic Fungus Isolated From Achyrocline satureioides Exhibits Selective Antiglioma Activity—The Role of Sch-642305. Frontiers in Oncology 8 (2018). doi:10.3389/fonc.2018.00476
  • Uccella, S. et al. New insights into hypoxia-related mechanisms involved in different microvascular patterns of bronchopulmonary carcinoids and poorly differentiated neuroendocrine carcinomas. Role of ribonuclease T2 (RNASET2) and HIF-1alpha. Hum Pathol 79, 66-76 (2018). doi:10.1016/j.humpath.2018.04.028
  • Wang, H. et al. Comparative proteomic profiling of human dental pulp stem cells and periodontal ligament stem cells under in vitro osteogenic induction. Archives of Oral Biology 89, 9-19 (2018). doi:https://doi.org/10.1016/j.archoralbio.2018.01.015
  • Cagnone, M. et al. A Pilot Study to Investigate the Balance between Proteases and alpha1-Antitrypsin in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients. High Throughput 8 (2019). doi:10.3390/ht8010005
  • Fontana, F. et al. Epithelial-to-mesenchymal transition markers and CD44 isoforms are differently expressed in 2D and 3D cell cultures of prostate cancer cells. Cells 8, 143 (2019).
  • Han, L. et al. The signaling mechanism of Hcy-induced atrial fibrosis mediated by TRPC3. bioRxiv, 583740 (2019). doi:10.1101/583740
  • Jentho, E. et al. Heme induces innate immunity memory. bioRxiv (2019).
  • Manda-Handzlik, A. et al. Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps. Cellular and Molecular Life Sciences (2019). doi:10.1007/s00018-019-03331-x
  • Maroli, A. et al. Effect of donepezil on the expression and responsiveness to LPS of CHRNA7 and CHRFAM7A in macrophages: A possible link to the cholinergic anti-inflammatory pathway. Journal of Neuroimmunology 332, 155-166 (2019). doi:https://doi.org/10.1016/j.jneuroim.2019.04.012
  • Mizuno, T., Kinoshita, S., Ito, T., Maedera, S. & Kusuhara, H. Development of orthogonal linear separation analysis (OLSA) to decompose drug effects into basic components. Scientific reports 9, 1-15 (2019).
  • Paganini, L. et al. A HS6ST2 gene variant associated with X‐linked intellectual disability and severe myopia in two male twins. Clinical genetics 95, 368-374 (2019).
  • De Vito, A. et al. Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection. Cancers (Basel) 12 (2020). doi:10.3390/cancers12030717
  • Han, L. et al. Protective mechanism of SIRT1 on Hcy‐induced atrial fibrosis mediated by TRPC3. Journal of Cellular and Molecular Medicine 24, 488-510 (2020).
  • Li, P., Butcher, N.J. & Minchin, R.F. Effect arylamine N-acetyltransferase 1 on morphology, adhesion, migration, and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin αV. Cell Adhesion & Migration 14, 1-11 (2020).
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  • Veschi, S. et al. Integrative proteomic and functional analyses provide novel insights into the action of the repurposed drug candidate nitroxoline in AsPC-1 cells. Scientific Reports 10, 2574 (2020). doi:10.1038/s41598-020-59492-4

 

WESTAR SUPERNOVA
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  • Mirasoli, M. et al. Multiplex chemiluminescence microscope imaging of P16 INK4A and HPV DNA as biomarker of cervical neoplasia. Analytical and bioanalytical chemistry 394, 981-987 (2009).
  • Girotti, S. et al. A quantitative chemiluminescent assay for analysis of peroxide-based explosives. Analytical and bioanalytical chemistry 400, 313-320 (2011).
  • Sciutto, G. et al. Development of a multiplexed chemiluminescent immunochemical imaging technique for the simultaneous localization of different proteins in painting micro cross-sections. Analytical and bioanalytical chemistry 399, 2889-2897 (2011).
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  • Dias, I.C.d.S. Indoleamina-2, 3-dioxigenase/quinurenina como potencial alvo farmacológico para tratar depressão associada ao diabetes. (2015).
  • Gomes, A.V. et al. Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. Journal of muscle research and cell motility 36, 447-461 (2015).
  • Greenwood, M. et al. Transcription factor CREB3L1 mediates cAMP and glucocorticoid regulation of arginine vasopressin gene transcription in the rat hypothalamus. Molecular brain 8, 68 (2015).
  • McDonald, C. Probing the membrane-binding and effector function of Phage Shock Protein A and its homologue Vipp1. (2015).
  • Schmitt, P. et al. Immunomodulatory effect of cathelicidins in response to a β-glucan in intestinal epithelial cells from rainbow trout. Developmental & Comparative Immunology 51, 160-169 (2015).
  • Tamang, A.P. (Nottingham Trent University, 2015).
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  • Wunderlich, A. et al. Rapid quantification method for Legionella pneumophila in surface water. Anal Bioanal Chem 408, 2203-2213 (2016).
  • Ojeda, N., Cardenas, C., Guzman, F. & Marshall, S.H. Chemical Synthesis and In Vitro Evaluation of a Phage Display-Derived Peptide Active against Infectious Salmon Anemia Virus. Appl Environ Microbiol 82, 2563-2571 (2016).
  • Manni, M.E. et al. Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target. Oxid Med Cell Longev 2016, 4375418 (2016).
  • Juraszek, B. & Nalecz, K.A. Protein phosphatase PP2A – a novel interacting partner of carnitine transporter OCTN2 (SLC22A5) in rat astrocytes. J Neurochem 139, 537-551 (2016).
  • Henriquez-Olguin, C. et al. NOX2 Inhibition Impairs Early Muscle Gene Expression Induced by a Single Exercise Bout. Front Physiol 7, 282 (2016).
  • Greenwood, M.P. et al. Rasd1, a small G protein with a big role in the hypothalamic response to neuronal activation. Mol Brain 9, 1 (2016).
  • Ghosh, R., Goswami, S.K., Feitoza, L., Hammock, B. & Gomes, A.V. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol 223, 923-935 (2016).
  • Duran, J. et al. GSK-3beta/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy. PLoS One 11, e0168255 (2016).
  • da Silva Dias, I.C. et al. Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes. Mol Neurobiol 53, 6997-7009 (2016).
  • Arena, C. et al. Ultrastructural, protein and photosynthetic alterations induced by Pb and Cd in Cynara cardunculus L., and its potential for phytoremediation. Ecotoxicology and environmental safety 145, 83-89 (2017).
  • Arena, C. et al. Eco-physiological and antioxidant responses of holm oak (Quercus ilex L.) leaves to Cd and Pb. Water, Air, & Soil Pollution 228, 459 (2017).
  • Castaño, E. et al. Folate transporters in placentas from preterm newborns and their relation to cord blood folate and vitamin B12 levels. PloS one 12 (2017).
  • Duran, J. et al. Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy. Frontiers in pharmacology 8, 604 (2017).
  • Estato, V. et al. Cerebral microvascular dysfunction and inflammation are improved by centrally acting antihypertensive drugs in metabolic syndrome. Metabolic syndrome and related disorders 15, 26-35 (2017).
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  • Gokulnath, M., Swetha, R., Thejaswini, G., Shilpa, P. & Selvamurugan, N. Transforming growth factor-β1 regulation of ATF-3, c-Jun and JunB proteins for activation of matrix metalloproteinase-13 gene in human breast cancer cells. International journal of biological macromolecules 94, 370-377 (2017).
  • Nisimura, Lindice Mitie. “Avaliação de tirosina hidroxilase e receptor\03B22 adrenérgico em leucócitos de sangue periférico na hipertensão.” PhD diss., 2017.
  • Silva, R.R.P. Efeito protetor do açaí (Euterpe oleracea Mart.) na doença hepática gordurosa não alcoólica mediado pelo aumento dos níveis de paraoxonase-1 e redução da oxidação de LDL em ratos. (2017).
  • Américo-Da-Silva, L. et al. A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization. The FASEB Journal 32, 4681-4695 (2018).
  • Arena, C. & Vitale, L. Chilling-induced reduction of photosynthesis is mitigated by exposure to elevated CO 2 concentrations. Photosynthetica 56, 1259-1267 (2018).
  • Arumugam, B., Balagangadharan, K. & Selvamurugan, N. Syringic acid, a phenolic acid, promotes osteoblast differentiation by stimulation of Runx2 expression and targeting of Smad7 by miR-21 in mouse mesenchymal stem cells. Journal of cell communication and signaling 12, 561-573 (2018).
  • Bdarny, M. et al. The AP-1 complex regulates AXL expression and determines sensitivity to PI3Kα inhibition in esophagus and head and neck squamous cell carcinoma. bioRxiv, 415752 (2018).
  • Bonora, E. et al. INPP 4B overexpression and c‐KIT downregulation in human achalasia. Neurogastroenterology & Motility 30, e13346 (2018).
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  • Díaz-Vegas, A. et al. Excitation-Metabolism Coupling in Skeletal Muscle: Ca²-Dependent O₂ Consumption and Spreading of Mitochondria Membrane Potential. Available at SSRN 3155798 (2018).
  • Díaz-Vegas, A.R. et al. Mitochondrial calcium increase induced by RyR1 and IP3R channel activation after membrane depolarization regulates skeletal muscle metabolism. Frontiers in physiology 9, 791 (2018).
  • Diquigiovanni, C. et al. In Troyer syndrome Spartin loss induces Complex I impairments and alters pyruvate metabolism. bioRxiv, 488239 (2018).
  • Fleith, R.C. et al. IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA. Nucleic acids research 46, 5269-5285 (2018).
  • Galarza, J.I., Gimpel, J.A., Rojas, V., Arredondo-Vega, B.O. & Henríquez, V. Over-accumulation of astaxanthin in Haematococcus pluvialis through chloroplast genetic engineering. Algal research 31, 291-297 (2018).
  • Giordano, F.C. Francesca Figlioli, Maria Cristina Sorrentino, Valeria Memoli, Carmen Arena, Giulia Maisto, Simonetta.
  • Krivitsky, A. et al. Molecular weight-dependent activity of aminated poly (α) glutamates as siRNA nanocarriers. Polymers 10, 548 (2018).
  • Kubo, H. et al. Rapid detection of metastatic lymph nodes of colorectal cancer with a gamma-glutamyl transpeptidase-activatable fluorescence probe. Scientific reports 8, 1-10 (2018).
  • Menon, A.H. et al. Sustained release of chrysin from chitosan-based scaffolds promotes mesenchymal stem cell proliferation and osteoblast differentiation. Carbohydrate polymers 195, 356-367 (2018).
  • Rattanaamnuaychai, P., Mekvichitsaeng, P., Poomputsa, K. & Roshorm, Y.M. Generation of a DNA vaccine expressing the porcine epidemic diarrhea virus immunogen fused with cholera toxin B subunit.
  • Slowik, A., Lammerding, L., Zendedel, A., Habib, P. & Beyer, C. Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia. The Journal of steroid biochemistry and molecular biology 183, 18-26 (2018).
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