EGS

Introduction

EGS is a homobifunctional amine-specific crosslinking reagent based on NHS-ester reactive groups for selective conjugation of primary amines.
EGS contains two NHS ester groups at both ends of a 12-atom spacer that readily react towards primary amines at pH 7-9.
EGS is not water soluble and must be dissolved in an organic solvent such as DMSO or DMF prior to use.
EGS is membrane permeable and can be used for intracelular crosslinking.
The crosslink formed when using EGS can be cleaved by treatment with hydroxylamine at 35°C at pH 8.5.

Properties/Highlights

Non-cleavable and membrane permeable
Readily reacts with primary amines in the pH range 7-9

Di(N-succinimidyl) ethylene glycol disuccinate, ethylene glycol bis-(N-hydroxysuccinimidylsuccinate)

C18H20N2O12

456.36 g/mol

128-132°C

Desiccated at -20°C under Argon. Product is shipped at ambient temperature.

≥ 98%

Complies

Acetic acid/water (1:1) up to 50 mg/ml and in DMF.

Order guide

Order-No.Unit SizePrice
H004N,0100100 mg50.00
H004N,0500500 mg85.00
H004N,10001 g150.00

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